5. Use of MSCs as carriers for anti-cancer therapy.
We have ongoing research interests to develop anti-cancer therapy using MSCs as delivery or homing vehicles. We have found that MSCs can home to cancer/tumor sites and delivered suicidal gene products into the tumor tissues, which can kill cancer cells and halt cancer growth. We have developed immortalized human MSCs cell line that over express thymidine kinase, which may be used for the treatment of cancer. We also reported that MSCs support tumor growth by providing angiogenetic factors and microenvironments for tumor initiating cells. We shall continue exploring the use of MSCs as delivery vehicles for anti-cancer therapy strategies.
PPT: The use of MSCs as anti-cancer vehicels |
Representative Publications:
1. Fu WM, Zhu X, Wang WM, Lu YF, Hu BG, Wang H, Liang WC, Wang SS, Ko CH,Waye MMY, Kung HF, Li G, Zhang JF. Hotair mediates hepatocarcinogenesis through suppressing MiRNA-218 expression and activating P14 and P16 signaling. Journal of Hepatology; 2015; 63(4): 886-95.
2. Lee WYW, Zhang T, Lau CPY, Wang CC, Chan KM, Li G. Immortalized human fetal bone marrow-derived mesenchymal stem cell expressing anti-tumor suicide gene for anti-tumor therapy in vitro and in vivo. Cytotherapy, 2013; 15:1484-1497.
3. Zhang T, Lee YW, Rui YF, Cheng TY, Jiang XH, Li G. Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors. Stem Cell Research & Therapy, 2013; 4:70.
4. Tang JQ, Zhang LY, She XL, Zhou GQ, Yu FL, Xiang JJ, Li G. Inhibiting CD164 expression in colon cancer cell line HCT116 leads to reduced cancer cell proliferation, mobility and metastasis in vitro and in vivo. Cancer Investigation, 2012 Jun; 30(5): 380-9.
5. Tang JQ, Luo ZH, Zhou GQ, Song C,Yu FL, Xiang JJ, Li G. Cis-regulatory functions of overlapping HIF-1alpha/E-box/AP-1-like sequences of CD164. BMC Molecular Biology, 2011; 12:44.
6. Song C, Li G. CXCR4 and MMP-2 are involved in mesenchymal stem cells homing and engraftment to the tumors. Cytotherapy, 2011; 13(5): 549-61.
7. Song C, Xiang J, Tang JQ, Hirst D, Zhou JW, Chan KM, Li G. Thymidine kinase gene modified bone marrow mesenchymal stem cells as vehicles for anti-tumor therapy. Human Gene Therapy , 2011; 22(4):439-49.
8. Bian ZY, Fan QM, Li G, Xu WT, Tang TT. Human mesenchymal stem cells promote growth of osteosarcoma: the involvement of interleukin-6 in the interaction between hMSCs and Saos-2 cells. Cancer Science, 2010; 101(12): 2554-60.
9. Xiang J, Tang JQ, Song C, Zhao L, Yang ZQ, Hirst DG, Li G. Mesenchymal stem cells as a gene therapy carrier for treatment of fibrosarcoma. Cytotherapy, 2009; 26:1-11.
10. Xu WT, Bian ZY, Fan QM, Li G, Tang TT. Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis. Cancer Letters, 2009; 281: 32-41. |